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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

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Products Intro: Product Name:Vilanterol Impurity 22（Vilanterol-d4 Triphenylacetate）
CAS:2021249-10-3
Purity:0.99 Package:10mg;25mg;50mg;100mg
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Products Intro: Product Name:Vilanterol
CAS:2021249-10-3
Purity:98% HPLC Package:25mg，50mg，100mg
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Products Intro: Product Name:Vilanterol Impurity 22 (Vilanterol-d4 Triphenylacetate)
CAS:2021249-10-3
Purity:99% HPLC Package:50G;10G;1G;500MG;100MG
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Products Intro: Product Name:Vilanterol Impurity 22（Vilanterol-D4 Triphenylacetate）
CAS:2021249-10-3
Purity:95%+ Package:10mg，50mg，100mg，200mg
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Products Intro: Product Name:Vilanterol-d4 triphenylacetate
CAS:2021249-10-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Basic information
Product Name:Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
Synonyms:Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
CAS:2021249-10-3
MF:C44H49Cl2NO7
MW:774.78
EINECS:
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Mol File:2021249-10-3.mol
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Structure
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties
solubility DMF: soluble; DMSO: soluble; Methanol: soluble
form A solid
Safety Information
MSDS Information
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Usage And Synthesis
DescriptionVilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
References1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010).
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials
Tag:Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)(2021249-10-3) Related Product Information
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