| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:IgG fraction of antiserum, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-CASK/LIN2 (KA-17) Basic information |
| | ANTI-CASK/LIN2 (KA-17) Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-CASK/LIN2 (KA-17) Usage And Synthesis |
| Uses | Anti-CASK/LIN2 (KA-17) antibody produced in rabbit is suitable for:
- immunoprecipitation at a concentraqtion of 5-10μg, using lysate of 3x105 cultured MDCK cells
- western blot (chemiluminescent) at a dilution of 1:300, using whole cell extract of cultured human Jurkat and dog MDCK kidney cells
| | General Description | Calcium/Calmodulin-dependent Serine Kinase (CASK/Lin-2) is predominant in the brain, may be ubiquitously expressed. It localizes to the lateral and/or basal plasma membrane regions in epithelial cells. | | Biochem/physiol Actions | CASK/Lin-2 (Calcium/Calmodulin-dependent Serine Kinase) is translocated into the nucleus to regulate gene expression. It interacts via its PDZ domain with the cytosolic tail of the transmembrane cell surface heparin sulfate proteoglycan Syndecan-2. In neurons it interacts with neurexins. In addition, CASK/Lin-2 is capable of interacting with the actinbinding band 1 protein, neuronal munc18-1-interacting protein 1(Mint-1/Lin-10), protein lin-7 homolog A (Veli/Lin-7) proteins, junctional adhesion molecule (JAM), disks large homolog 1 (hDlg), and the nuclear T-box brain transcription factor 1 (Tbr-1). |
| | ANTI-CASK/LIN2 (KA-17) Preparation Products And Raw materials |
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