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L-NORPSEUDOEPHEDRINE

L-NORPSEUDOEPHEDRINE Basic information
Product Name:L-NORPSEUDOEPHEDRINE
Synonyms:L-NORPSEUDOEPHEDRINE;(-) -Pseudonorephedrine, (1R,2R)-2-Amino-1-phenyl-1-propanol, (R,R)-α-(1-Aminoethyl)benzenemethanol, L-(-)-Norpseudoephedrine;(1R,2R)-(-)-Norpseudoephedrine;(1R,2R)-2-Amino-1-phenylpropane-1-ol;(R)-α-[(R)-1-Aminoethyl]benzenemethanol;(-)-threo-2-AMino-2-Methyl-1-phenylethanol;(1R,2R)-2-AMino-1-phenyl-1-propanol;(R,R)-(-)-Norpseudoephedrine
CAS:37577-07-4
MF:C9H13NO
MW:151.21
EINECS:
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Neurochemicals;Pharmaceuticals
Mol File:37577-07-4.mol
L-NORPSEUDOEPHEDRINE Structure
L-NORPSEUDOEPHEDRINE Chemical Properties
Melting point 77-78 °C
Boiling point 288.1±20.0 °C(Predicted)
density 1.071±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka12.07±0.45(Predicted)
EPA Substance Registry SystemBenzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)- (37577-07-4)
Safety Information
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
RIDADR UN 2811 6.1/PG 3
MSDS Information
L-NORPSEUDOEPHEDRINE Usage And Synthesis
UsesAn enatiomer of (+)-Pseudonorephedrine (P839585). (-)-Pseudonorephedrine is metabolite of Cathinone (C225700) and possesses amphetamine-like stimulus properties. Studies show that (-)-Pseudonorephedri ne enhances the analgesic and rate decreasing effects of Morphine (M652290) but inhibits discriminative properties.
DefinitionChEBI: Phenylpropanolamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations. It has a role as a sympathomimetic agent and a nasal decongestant.
Purification MethodsPurify (-)-nor--ephedrine by recrystallisation from H2O, MeOH, EtOH, Et2O/pet ether or *C6H6 (plates). The mandelate salt has m 163.5o (from EtOH/Et2O) and [] D -41.3o (c 0.8, H2O) [Jarowski & Hartung J Org Chem 8 564 566 567 1943]. The hydrochloride is purified by dissolving 1.44g in 96% EtOH (5mL), adding Et2O (16mL) and cooling; it has m 178-179o (m180-181o is also reported) and [] 30D -42.9o (c 1.8, H2O) [Fles & Markovac-Prpic Croat Chem Acta 29 186 1957]. [Beilstein 13 I 252, 13 II 370, 13 III 1716, 13 IV 1874.]
L-NORPSEUDOEPHEDRINE Preparation Products And Raw materials
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