Mizagliflozin
中文名称 | Mizagliflozin |
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中文同义词 | 化合物MIZAGLIFLOZIN;3 - ((3-(4 - ((5-异丙基-3 - (((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃 2-基)氧基)-1H-吡唑-4-基)甲基)-3-甲基苯氧基)丙基)氨基)-2,2-二甲基丙酰胺;DSP-3235 |
英文名称 | Mizagliflozin |
英文同义词 | Mizagliflozin;DSP-3235 free base;GSK-1614235 free base;KGA-3235 free base;Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-2,2-dimethyl-;GSK1614235,Chronic,KGA 3235,DSP-3235,selective,Sodium-dependent glucose cotransporters,KGA-3235,constipation,Mizagliflozin,antidiabetic,disorder,SGLT,gastrointestinal,DSP 3235,inhibit,GSK 1614235,Inhibitor,KGA3235,GSK-1614235,DSP3235;Mizagliflozin (KWA 0711);GSK 1614235 |
CAS号 | 666843-10-3 |
分子式 | C28H44N4O8 |
分子量 | 564.68 |
EINECS号 | |
相关类别 | |
Mol文件 | 666843-10-3.mol |
结构式 | ![]() |
Mizagliflozin 性质
沸点 | 837.0±65.0 °C(Predicted) |
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密度 | 1.274±0.06 g/cm3(Predicted) |
储存条件 | 4°C, protect from light |
溶解度 | 甲醇:250 mg/mL (442.74 mM);二甲基亚砜:100 mg/mL(177.09 mM) |
形态 | 固体 |
酸度系数(pKa) | 12.65±0.70(Predicted) |
颜色 | 米白色至浅黄色 |
Mizagliflozin (KWA 0711)是一种新型、有效、选择性的 sodium glucose co-transporter 1 (SGLT1) 抑制剂,对human SGLT1的Ki值为27 nM。Mizagliflozin的选择性比(Ki value for human SGLT2/Ki value for human SGLT1)为303。Mizagliflozin还有改善慢性便秘的潜在应用。
Target | Value |
human SGLT1
(Cell-free assay) | 27 nM(Ki) |
Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect.
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)
Animal Model: | Male Wistar rats (rat model of low-fiber-diet-induced constipation) |
Dosage: | 3, 10, 30 mg/kg |
Administration: | Oral |
Result: | Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-17638 | Mizagliflozin | 1 mg | 909元 | |
2024/04/30 | HY-17638 | Mizagliflozin Mizagliflozin | 666843-10-3 | 5mg | 2000元 |