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Energy Chemical
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021-58432009 400-005-6266 |
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Product Name:N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide >=98% (HPLC), solid CAS:300670-16-0 Purity:NULL Package:25mg;5mg Remarks:NULL
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| N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI Basic information |
Product Name: | N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI | Synonyms: | N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI;Benzamide, N-(4-bromophenyl)-3-(((4-bromophenyl)amino)sulfonyl);Polyglutamine Aggregation Inhibitor III, C2-8;C2-8
(polyQ aggregation inhibitor C2-8);N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide >=98% (HPLC), solid | CAS: | 300670-16-0 | MF: | C19H14Br2N2O3S | MW: | 510.2 | EINECS: | | Product Categories: | | Mol File: | 300670-16-0.mol | ![N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI Structure](CAS/GIF/300670-16-0.gif) |
| N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI Chemical Properties |
density | 1.760±0.06 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMSO: ~20 mg/mL | pka | 7.49±0.10(Predicted) | form | solid | color | off-white |
Hazard Codes | Xi | Risk Statements | 36 | Safety Statements | 26 | WGK Germany | 3 |
| N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI Usage And Synthesis |
Description | C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington''s disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington''s disease. |
| N-(4-BROMOPHENYL)-3-{[(4-BROMOPHENYL)AMI Preparation Products And Raw materials |
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