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Products Intro: |
Product Name:CDK8-IN-1 CAS:1629633-48-2 Purity:98% Package:5mg;10mg;20mg;50mg;100mg;200mg
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| CDK8-IN-1 Basic information |
Product Name: | CDK8-IN-1 | Synonyms: | CDK8-IN-1;CDK8-IN-16;CDK8IN1,CDK-8-IN-1,CDK8 IN 1;1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)- | CAS: | 1629633-48-2 | MF: | C11H8F3N3O | MW: | 255.2 | EINECS: | | Product Categories: | | Mol File: | 1629633-48-2.mol | |
| CDK8-IN-1 Chemical Properties |
Boiling point | 406.2±45.0 °C(Predicted) | density | 1.429±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | Solid | pka | 12.46±0.50(Predicted) | color | White to light brown |
| CDK8-IN-1 Usage And Synthesis |
Description | CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1]. | References | [1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492. |
| CDK8-IN-1 Preparation Products And Raw materials |
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