| Company Name: |
Boao Pike
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| Tel: |
010-57798038 15652371397 |
| Email: |
lyn@biopike.com.cn |
| Products Intro: |
Product Name:Osteocrin
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| Product Name: | Osteocrin | | Synonyms: | Osteocrin | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Osteocrin Structure]() |
| | Osteocrin Chemical Properties |
| | Osteocrin Usage And Synthesis |
| Discovery | Using single-sequence trap methods, two different
groups identified the same peptide with similarity to
natriuretic peptides from the bone in 2003 (named
OSTN), and from the muscle in 2004 (named musclin). | | Gene and mRNA | The human OSTN gene (OSTN) is located on chromosome
3 (3q28) while ANP (NPPA)/BNP (NPPB) (1p36)
and CNP (NPPC) (2q37) are located on different chromosomes.
The human OSTN mRNA is 3231bp (402bp coding
sequence). Like BNP mRNA, repetitive AUUUA
motifs in the 30-untranslated region are present in
humans and Xenopus OSTN mRNAs. However, some
species, including mice, chickens, and zebrafish, do not
possess this motif. | | ?Target cells/tissues and functions | Although OSTN was originally found to inhibit osteoblast
activity in vitro,the main action of OSTN is blocking
the clearance activity of NPR-C. The effect increases
the circulating CNP level and reinforces CNP/NPR-B
binding.Therefore, OSTN is thought to be amodulator
of circulating CNP.OSTN
expresses in the muscle, which may act as a myokine.However, the target cells are unknown. | | General Description | OSTN contains two natriuretic peptide motifs, and is
expressed mainly in the bones and muscle. It is thought to
be an endogenous specific ligand for the clearance natriuretic
peptide receptor (NPR-C) and to modulate CNP levels by
blocking NPR-C activity. |
| | Osteocrin Preparation Products And Raw materials |
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