3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
| 中文名称 | 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- |
|---|---|
| 中文同义词 | 化合物 T15819;化合物 LY377604 |
| 英文名称 | 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- |
| 英文同义词 | 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-;LY377604;LY-377604,LY377604 |
| CAS号 | 204592-94-9 |
| 分子式 | C31H32N4O4 |
| 分子量 | 524.61 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 204592-94-9.mol |
| 结构式 | ![3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- 结构式](CAS/20200515/GIF/204592-94-9.gif) |
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- 性质
| 沸点 | 809.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.282±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.94±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至浅棕色 |
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- 用途与合成方法
EC50: 2.4 nM (human β 3 -adrenergic receptor) β 1 -adrenergic receptor, β 2 -adrenergic receptor
LY377604 is a human β 3 -adrenergic receptor agonist with an EC 50 of 2.4 nM and also a β 1 - and β 2 -adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β 1 adrenergic receptor or the human β 2 adrenergic receptor.
Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.