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Shanghai Chaolan Chemical Technology Center
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Product Name:PHD-1-IN-1 CAS:2009343-14-8 Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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DC Chemicals
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Product Name:PHD-1-IN-1 CAS:2009343-14-8 Purity:98% HPLC Package:100mg,250mg,1g
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| Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Basic information |
Product Name: | Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- | Synonyms: | Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl-;PHD-1-IN-1;pocket,ion,Arg367-out,HIF-PH,Hypoxia-inducible factors,site,active,PHD 1 IN 1,orally,Inhibitor,PHD-1,Fe2+,PHD1IN1,iron,HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit | CAS: | 2009343-14-8 | MF: | C13 H8 N4 | MW: | 220.23 | EINECS: | | Product Categories: | | Mol File: | 2009343-14-8.mol | ![Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Structure](CAS/20200515/GIF/2009343-14-8.gif) |
| Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Chemical Properties |
storage temp. | Store at -20°C | solubility | DMSO : 195 mg/mL (885.44 mM; Need ultrasonic) | form | Solid | color | White to off-white |
| Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Usage And Synthesis |
Biological Activity | PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an "Arg367-out" pocket[1].
PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95[1]. | References | [1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672. |
| Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Preparation Products And Raw materials |
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