Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:CAY10736 CAS:2251753-61-2 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:CAY10736 CAS:2251753-61-2 Purity:90% Package:500μg;1mg
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:CAY10736 CAS:2251753-61-2 Package:1mg/RMB 3810
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CAY10736 manufacturers
- CAY10736
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- $545.00 / 1mg
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2024-10-24
- CAS:2251753-61-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| CAY10736 Basic information |
Product Name: | CAY10736 | Synonyms: | CAY10736;Olean-12-en-28-amide, N-[2-[[[(4-methoxyphenyl)amino]thioxomethyl]amino]ethyl]-2-methylene-3-oxo-;N-[2-[[[(4-methoxyphenyl)amino]thioxomethyl]amino]ethyl]-2-methylene-3-oxo-olean-12-en-28-amide | CAS: | 2251753-61-2 | MF: | C41H59N3O3S | MW: | 673.99 | EINECS: | | Product Categories: | | Mol File: | 2251753-61-2.mol | |
| CAY10736 Chemical Properties |
density | 1.15±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Chloroform: soluble; Ethanol: soluble | form | A crystalline solid | pka | 12.58±0.70(Predicted) |
| CAY10736 Usage And Synthesis |
Description | CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model. | References | 1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids J. Med. Chem. 61(23),10814-10833(2018). |
| CAY10736 Preparation Products And Raw materials |
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