| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CU-32
CAS:2400954-16-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CU-32;CU32,CU 32
CAS:2400954-16-5
Purity:98% Package:25 mg
|
| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
|
| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate
CAS:2400954-16-5
Purity:95+% Package:1g;5g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CU-32
CAS:2400954-16-5
Purity:98% Package:1mg;5mg;10mg
|
|
| Product Name: | CU-32 | | Synonyms: | CU-32;CU32,CU 32;1,3,5-Triazine-2-carboxylic acid, 4-amino-6-[(4-iodophenyl)amino]-, methyl ester;methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate | | CAS: | 2400954-16-5 | | MF: | C11H10IN5O2 | | MW: | 371.13 | | EINECS: | | | Product Categories: | | | Mol File: | 2400954-16-5.mol |  |
| | CU-32 Chemical Properties |
| Boiling point | 537.0±52.0 °C(Predicted) | | density | 1.880±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | | form | A crystalline solid | | pka | 3.11±0.10(Predicted) |
| | CU-32 Usage And Synthesis |
| Biological Activity | CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.45 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. | | References | 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020) |
| | CU-32 Preparation Products And Raw materials |
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