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Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:Anti-p57Kip2
Purity:IgG fraction of antiserum, buffered aqueous solution Package:0.1mg, 200μg Remarks:P0357
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| | ANTI-KIP2 Basic information |
| Product Name: | ANTI-KIP2 | | Synonyms: | MONOCLONAL ANTI-P57KIP2;ANTI-ONCOPROTEIN P57;ANTI-P57KIP2;ANTI-P57 PROTEIN;ANTI-MITOTIC INHIBITOR/SUPPRESSOR PROTEIN;ANTI-KIP2;Anti-p57Kip2 antibody produced in rabbit;Monoclonal Anti-p57Kip2 antibody produced in mouse | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-KIP2 Structure]() |
| | ANTI-KIP2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-KIP2 Usage And Synthesis |
| Uses | Anti-p57Kip2 antibody produced in rabbit has been used in Western blotting. | | General Description | Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) is a tumor suppressor gene. It is a 316 amino acid protein with conserved amino- and carboxy-terminal domains and sequences with proline-alanine repeats. During mouse embryogenesis, p57KIP2 transcript is highly expressed in skeletal muscles, brain, heart, lungs and eye. The gene encoding this protein is localized on human chromosome 11p15.4.
| | Biochem/physiol Actions | Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) plays a vital role as a tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (CDK) complexes. It is a negative regulator of cell proliferation. Mutation in this gene has been associated with Beckwith-Wiedemann syndrome. p57Kip2 facilitates direct inhibition of DNA replication by binding to the proliferating cell nuclear antigen. |
| | ANTI-KIP2 Preparation Products And Raw materials |
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