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| | Z-LEHD-FMK Basic information |
| Product Name: | Z-LEHD-FMK | | Synonyms: | BENZYLOXYCARBONYL-LEU-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE;CASPASE-9 INHIBITOR;CASPASE-9 INHIBITOR (FLUOROMETHYLKETONE);CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEHD-FMK;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE;Z-LE(OME)HD(OME)-FMK | | CAS: | 210345-04-3 | | MF: | C32H43FN6O10 | | MW: | 690.73 | | EINECS: | | | Product Categories: | Caspases/Apoptosis;Caspase/Related Products | | Mol File: | Mol File |  |
| | Z-LEHD-FMK Chemical Properties |
| Boiling point | 1008.2±65.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO. | | form | powder | | pka | 11.11±0.46(Predicted) | | color | White to yellow |
| | Z-LEHD-FMK Usage And Synthesis |
| Uses | A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition | | Biological Activity | Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo . | | references | [1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.
[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.
[3]. colak a, karaoğlan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334. |
| | Z-LEHD-FMK Preparation Products And Raw materials |
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