|
|
| | ANTI-MOUSE IL-10 Basic information |
| Product Name: | ANTI-MOUSE IL-10 | | Synonyms: | ANTI-IL-10, MOUSE;ANTI-IL-10;ANTI-MOUSE IL-10 POLYCLONAL ANTIBODY;ANTI-MOUSE IL-10R;ANTI-MOUSE IL-10 R-ALPHA EXTRACELLULAR DOMAIN;ANTI-MOUSE IL-10;ANTI-MOUSE IL-10, CLONE JES5-2A5;ANTI-MOUSE IL-10, CLONE JES5-2A5, MONOCLONAL ANTIBODY | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | 202-739-6 | | Product Categories: | | | Mol File: | Mol File | ![ANTI-MOUSE IL-10 Structure]() |
| | ANTI-MOUSE IL-10 Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder |
| | ANTI-MOUSE IL-10 Usage And Synthesis |
| Uses | Anti-interleukin-10 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is suitable for neutralization reactions (ND50 is 2-4 μg/ml). | | General Description | Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. The production of IL-10 is mediated by signalling of IL-6, IL-12 and TGF-β. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10 is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10 production is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Anti-interleukin-10 antibody is specific for mouse IL-10. The antibody shows less than 5% cross reactivity to recombinant human IL-10. |
| | ANTI-MOUSE IL-10 Preparation Products And Raw materials |
|