| Company Name: |
Absin Bioscience Inc.
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| Tel: |
021-38015121 |
| Email: |
chenjw@absin.cn |
| Products Intro: |
Product Name:ERK Inhibitor
CAS:294675-79-9
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| | 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Basic information |
| | 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥4mg/mL | | form | powder | | color | off-white |
| | 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Usage And Synthesis |
| Uses | 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries. | | Biochem/physiol Actions | 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2. |
| | 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Preparation Products And Raw materials |
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