| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:EPAC 5376753
CAS:302826-61-5
Purity:98% Package:1 mg;10 mg;100 mg;25 mg;5 mg;50 mg
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| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:EPAC 5376753
Purity:98% by TLCNMR (Conforms) Package:$60.00/5mg;$240.00/25mg;
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| | EPAC 5376753 Basic information |
| Product Name: | EPAC 5376753 | | Synonyms: | EPAC 5376753;4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo- | | CAS: | 302826-61-5 | | MF: | C15H8Cl2N2O3S | | MW: | 367.21 | | EINECS: | | | Product Categories: | | | Mol File: | 302826-61-5.mol |  |
| | EPAC 5376753 Chemical Properties |
| density | 1.63±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml) | | form | solid | | pka | 4.86±0.20(Predicted) | | color | Orange-red | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
| | EPAC 5376753 Usage And Synthesis |
| Description | EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2 | | References | 1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148
2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203 |
| | EPAC 5376753 Preparation Products And Raw materials |
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