| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PI3K/HDAC-IN-1
CAS:2361418-52-0
Purity:0 Package:25mg/RMB 11700;100mg/RMB 19500;50mg/RMB 15300
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| | PI3K/HDAC-IN-1 Basic information |
| Product Name: | PI3K/HDAC-IN-1 | | Synonyms: | PI3K/HDAC-IN-1;PI-3K/HDAC-IN-1,PI3K/HDAC IN 1,PI3K/HDACIN1;Heptanamide, 7-[[6-(5-fluoro-6-methoxy-3-pyridinyl)-4-methyl-8-quinazolinyl]oxy]-N-hydroxy- | | CAS: | 2361418-52-0 | | MF: | C22H25FN4O4 | | MW: | 428.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2361418-52-0.mol |  |
| | PI3K/HDAC-IN-1 Chemical Properties |
| density | 1.262±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.47±0.20(Predicted) |
| | PI3K/HDAC-IN-1 Usage And Synthesis |
| Description | PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1].
PI3Kα|42 nM (IC50)|PI3Kβ|101 nM (IC50)|PI3Kγ|67 nM (IC50)|PI3Kδ|8.1 nM (IC50)|HDAC1|1.4 nM (IC50)|HDAC2|3.0 nM (IC50)|HDAC6|6.6 nM (IC50)|HDAC8|18 nM (IC50)
| | References | [1]. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29. |
| | PI3K/HDAC-IN-1 Preparation Products And Raw materials |
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