PROTAC AR Degrader-4
| 中文名称 | PROTAC AR Degrader-4 |
|---|---|
| 中文同义词 | |
| 英文名称 | PROTAC AR Degrader-4 |
| 英文同义词 | PROTAC AR Degrader-4;Androstan-3-one, 17-[[(14S,17S,18R)-18-amino-17-hydroxy-14-(2-methylpropyl)-1,13,16-trioxo-19-phenyl-3,6,9-trioxa-12,15-diazanonadec-1-yl]oxy]-, (5α,17β)- |
| CAS号 | 1351169-31-7 |
| 分子式 | C43H67N3O9 |
| 分子量 | 770.01 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1351169-31-7.mol |
| 结构式 |  |
PROTAC AR Degrader-4 性质
| 沸点 | 906.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.19±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 10.90±0.45(Predicted) |
PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。
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cIAP1
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Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.