| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:DSHN >=98% (HPLC)
CAS:313952-63-5
Purity:NULL Package:25mg;5mg Remarks:NULL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:DSHN;DSHN
CAS:313952-63-5
Purity:98% Package:5 mg
|
|
| | DSHN >=98% (HPLC) Basic information |
| | DSHN >=98% (HPLC) Chemical Properties |
| Boiling point | 519.7±60.0 °C(Predicted) | | density | 1.387±0.06 g/cm3(Predicted) | | pka | 2.73±0.30(Predicted) |
| | DSHN >=98% (HPLC) Usage And Synthesis |
| Description | DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). DSHN transcriptionally activates SHP mRNA, but also stabilizes the SHP protein by preventing its ubiquitination and degradation. | | Definition | ChEBI: 5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid is a member of naphthalenes and a sulfonic acid derivative. | | in vivo | DSHN transcriptionally activated Shp mRNA, but also stabilized the SHP protein by preventing its ubiquitination and degradation. Second, this study identified Ccl2 as a new SHP target gene by RNA-seq. This study showed that activation of SHP by DSHN repressed Ccl2 expression and secretion by inhibiting p65 activation of CCL2 promoter activity, as demonstrated in vivo in Shp-/- mice and in vitro in HCC cells with SHP overexpression and knockdown._x000D_
_x000D_
Reference: Mol Cancer Ther. 2016 Oct;15(10):2294-2301. https://pubmed.ncbi.nlm.nih.gov/27486225/ | | target | DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). |
| | DSHN >=98% (HPLC) Preparation Products And Raw materials |
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