| Company Name: |
Chengdu Novel Biomedical Co., Ltd.
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| Tel: |
028-85255396 18302801538 |
| Email: |
cdnovell@163.com |
| Products Intro: |
Product Name:PROTAC PD-1
CAS:2447066-37-5
Purity:95% Package:5g;10g
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
| Products Intro: |
Product Name:PROTAC PD-1/PD-L1 degrader-1
CAS:2447066-37-5
Purity:98% HPLC Package:1mg Remarks:V34656
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:PROTAC PD-1/PD-L1 degrader-1
CAS:2447066-37-5
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| | PROTAC PD-1/PD-L1 degrader-1 Basic information |
| | PROTAC PD-1/PD-L1 degrader-1 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, sealed storage, away from moisture and light | | solubility | DMSO : 210 mg/mL (195.06 mM; Need ultrasonic) | | pka | 10.69±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | PROTAC PD-1/PD-L1 degrader-1 Usage And Synthesis |
| Biological Activity | PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1].
PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1].PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively[1]. | | References | [1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. |
| | PROTAC PD-1/PD-L1 degrader-1 Preparation Products And Raw materials |
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