诺次黄嘌呤外消旋体
| 中文名称 | 诺次黄嘌呤外消旋体 |
|---|---|
| 中文同义词 | 诺次黄嘌呤外消旋体;化合物 T12245 |
| 英文名称 | 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one |
| 英文同义词 | 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-6H-purin-6-one;9-[1-(1-Hydroxyethyl)heptyl]hypoxanthine;Erimunol;Nosantine (racemate);6H-Purin-6-one, 1,9-dihydro-9-[1-(1-hydroxyethyl)heptyl]-;NPT-15392 racemate |
| CAS号 | 75166-67-5 |
| 分子式 | C14H22N4O2 |
| 分子量 | 278.35 |
| EINECS号 | 278-092-9 |
| 相关类别 | |
| Mol文件 | 75166-67-5.mol |
| 结构式 |  |
诺次黄嘌呤外消旋体 性质
| 沸点 | 539.1±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.84±0.70(Predicted) |
IL-2
The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations.
Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions.