| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
0575-18780151478 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Geldanamycin-FITC
CAS:2969156-01-0
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
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| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:Geldanamycin-FITC
Purity:98% by TLCNMR (Conforms) Package:$200.00/1mg;$600.00/5mg;
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| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.com |
| Products Intro: |
Product Name:Geldanamycin-FITC
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| | Geldanamycin-FITC Basic information |
| | Geldanamycin-FITC Chemical Properties |
| storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (greater than 10 mg/ml) | | form | solid | | color | Purple | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | Geldanamycin-FITC Usage And Synthesis |
| Description | Geldanamycin-FITC is a novel geldanamycin fluorescent probe1?that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3?May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of?in vitro?pharmacology to cellular and?in vivo?efficacy.4 | | Uses | Geldanamycin-FITC is a novel geldanamycin fluorescent probe. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy. | | References | 1) Llauger-Bufi?et al. (2003),?Synthesis of novel fluorescent probes for the molecular chaperone Hsp90;? Bioorg. Med. Chem. Lett.,?13?3975
2) Kim?et al. (2004),?Development of a fluorescent polarization assay for the molecular chaperone Hsp90;? J. Biomol. Screen.,?9?375
3) Austin?et al. (2012),?Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors;? J. Biomol. Screen.,?17?868
4) Gooljarsingh?et al. (2006),?A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues;? Proc. Natl. Acad. Sci. USA,?103?7625 |
| | Geldanamycin-FITC Preparation Products And Raw materials |
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