| Company Name: |
United States Biological
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| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:BAY U6751
CAS:114290-51-6
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
CAS:114290-51-6
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | BAY U6751 HYDRATE Basic information |
| Product Name: | BAY U6751 HYDRATE | | Synonyms: | 4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate;BAY U6751 | | CAS: | 114290-51-6 | | MF: | C20H20ClNNa2O6 | | MW: | 451.80844 | | EINECS: | | | Product Categories: | | | Mol File: | 114290-51-6.mol |  |
| | BAY U6751 HYDRATE Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: >8mg/mL | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | BAY U6751 HYDRATE Usage And Synthesis |
| Biochem/physiol Actions | BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output. |
| | BAY U6751 HYDRATE Preparation Products And Raw materials |
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