| Company Name: |
ChemeGen 中国
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Fenspiride-d5
CAS:1246911-67-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Fenspiride-d5
CAS:1246911-67-0
Purity:>95% Package:1mg;5mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:Fenspiride-d5
CAS:1246911-67-0
Purity:详情请点击官网 Package:1 mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Fenspiride-d5
CAS:1246911-67-0
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| | Fenspiride-d5 Basic information |
| | Fenspiride-d5 Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble,Methanol: soluble | | form | A solid |
| | Fenspiride-d5 Usage And Synthesis |
| Biological Activity | Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID).1,2 It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 μM, respectively, in isolated human bronchi derived from patients with lung cancer).3 It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric acid in a guinea pig model of cough.2 | | References | 1.Rognoni, F., Marchini, F., Piacenza, G., et al.Effect of 8-N-phenethyl-1-oxa-2-oxo-3,8-diazaspiro(4,5)decane hydrochloride (decaspiride) on histamine receptorsBoll. Chim. Farm.117(7)397-401(1978)
2.Laude, E.A., Bee, D., Crambes, O., et al.Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigsEur. Respir. J.8(10)1699-1704(1995)
3.Cortijo, J., Naline, E., Ortiz, J.L., et al.Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Functional and biochemical studyEur. J. Pharmacol.341(1)79-86(1998) |
| | Fenspiride-d5 Preparation Products And Raw materials |
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