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L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-

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L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:HeE1-2Tyr
CAS:2245195-67-7
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:HeE1-2Tyr
CAS:2245195-67-7
Purity:96% Package:$250.9/5mg;$400.9/10mg;$850.9/25mg;$1350.9/50mg;Bulk package Remarks:96%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Products Intro: Product Name:HeE1-2Tyr
CAS:2245195-67-7
Purity:98% Package:1g;10g;100g
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:HeE1-2Tyr
CAS:2245195-67-7
Purity:98% Package:1g/
Company Name: Kaifeng Mingren Pharmaceutical Co.,LTD  
Tel: 0371-65741762
Email: sales@hasunny.com
Products Intro: Product Name:HeE1-2Tyr
CAS:2245195-67-7
Purity:98% Package:10mg
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Basic information
Product Name:L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-
Synonyms:L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-;HeE1-2Tyr;HeE12Tyr,Nile,West,SARS-CoV,HeE1 2Tyr,SARS coronavirus,RdRp,HeE1-2Tyr,inhibit,HeE-1-2Tyr,flavivirus,Dengue,Inhibitor
CAS:2245195-67-7
MF:C33H30N2O6S
MW:582.67
EINECS:
Product Categories:
Mol File:2245195-67-7.mol
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Structure
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Chemical Properties
Boiling point 842.3±65.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (171.62 mM; Need ultrasonic)
pka3.06±0.10(Predicted)
form Solid
color White to yellow
Safety Information
MSDS Information
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Usage And Synthesis
Biological ActivityHeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro[1][2]. HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM[1].Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM[1]. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].
References[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Preparation Products And Raw materials
Tag:L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-(2245195-67-7) Related Product Information