Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:DDX3-IN-2 CAS:1919828-81-1 Purity:98% Package:100 mg;200 mg
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Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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Tel: |
021-59167510 18117107507 |
Email: |
vip@med-life.cn |
Products Intro: |
Product Name:DDX3-IN-2 CAS:1919828-81-1 Purity:>=99% Package:5mg;500mg;50mg;25mg;200mg;100mg;10mg;10mM*1mLinDMSO
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Company Name: |
RD International Technology Co., Limited
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Tel: |
18024082417 |
Email: |
market@ubiochem.com |
Products Intro: |
Product Name:DDX3-IN-2 CAS:1919828-81-1 Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Basic information |
| Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Chemical Properties |
density | 1.18±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | form | Solid | pka | 13.83±0.70(Predicted) | color | Off-white to gray |
| Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Usage And Synthesis |
Biological Activity | DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance[1].
DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase[1].
DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg[1].DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values[1]. | References | [1]. Brai A, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. 2016;113(19):5388-5393. |
| Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Preparation Products And Raw materials |
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