| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:ALV2
CAS:2438124-95-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10mg，more
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| | Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Basic information |
| | Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Chemical Properties |
| Boiling point | 724.8±60.0 °C(Predicted) | | density | 1.444±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 160 mg/mL (305.36 mM; Need ultrasonic)| | | pka | 10.69±0.40(Predicted) | | form | Solid | | color | White to yellow | | Water Solubility | Water : < 0.1 mg/mL (insoluble) |
| | Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Usage And Synthesis |
| Biological Activity | ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1].
ALV2 (10 nM-100 μM) induces CRBN-Helios dimerization in the TR-FRET assay[1].ALV2 (0.1-10 μM) preferentially promotes Helios degradation in Jurkat cells[1].ALV2 (1 μM; pretreated for 18 h) promotes IL-2 secretion in Jurkat cells[1].
ALV2 (100 mg/kg; i.p. twice daily for 7 days) induces selective Helios degradation in vivo[1]. | | References | [1]. Wang ES, et, al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717. |
| | Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Preparation Products And Raw materials |
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