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| | INDEX NAME NOT YET ASSIGNED 製品概要 |
| 化学名: | | | 英語化学名: | INDEX NAME NOT YET ASSIGNED | | 别名: | DBCO-PEG4-VA-SG3132 | | CAS番号: | 2241644-09-5 | | 分子式: | C80H87N9O16 | | 分子量: | 1430.6 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 2241644-09-5.mol |  |
| | INDEX NAME NOT YET ASSIGNED 物理性質 |
| 比重(密度) | 1.30±0.1 g/cm3(Predicted) | | 酸解離定数(Pka) | 13.55±0.70(Predicted) | | 外見 | Solid | | 色 | White to light yellow |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| 使用 | DBCO-PEG4-VA-PBD is a agent-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA[1]. DBCO-PEG4-VA-PBD is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | 生物活性 | DBCO-PEG4-VA-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, Pyrrolobenzodiazepine (PBD), linked via DBCO-PEG4-VA[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. | | IC 50 | Traditional Cytotoxic Agents | | 参考文献 | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
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