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2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-

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2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Suppliers list
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:TMX-4100
CAS:2367619-63-2
Purity:98%
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Products Intro: Product Name:TMX-4100
CAS:2367619-63-2
Purity:98% HPLC Package:1g
Company Name: Changzhou Bojia Biomedical Technology Co., Ltd.  
Tel: 2122619822
Email: czbjpharma@126.com
Products Intro: CAS:2367619-63-2
Purity:98% Package:1g；5g；10g；100g; 1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:TMX-4100
CAS:2367619-63-2
Purity:90+%，具体纯度信息请见官网 Package:2mg/RMB 1470;5mg/RMB 2490;10mg/RMB 4180
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:TMX-4100
CAS:2367619-63-2
Purity:95.00% Package:2mg;5mg;10mg
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Basic information
Product Name:2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-
Synonyms:2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]-;TMX-4100;3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione
CAS:2367619-63-2
MF:C11H10N4O2S
MW:262.29
EINECS:
Product Categories:
Mol File:2367619-63-2.mol
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Structure
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Chemical Properties
density 1.65±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka10.45±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Usage And Synthesis
Biological ActivityTMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1].TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1].TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1].
References[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.
2,6-Piperidinedione, 3-[4-(3-thienyl)-1H-1,2,3-triazol-1-yl]- Preparation Products And Raw materials
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