| Company Name: |
Shanghai Send Pharmaceutical Technology Co., Ltd.
|
| Tel: |
021-58088081 Q3252066219 |
| Email: |
danping@shsendpharm.com |
| Products Intro: |
Product Name:Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
CAS:2377474-67-2
Purity:95% Package:1g;5g;10g
|
| Company Name: |
Shochem(Shanghai)Co.,Ltd
|
| Tel: |
+86-021-51783479 +86-13816874662 |
| Email: |
info@shochem.com |
| Products Intro: |
Product Name:Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1′-[dithiobis(2,1-ethanediyl-1,4-pip eridinediyl-2,1-ethanediyl)] ester
CAS:2377474-67-2
Purity:98% Package:1g;10g;100g
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:ssPalmO-Phe
CAS:2377474-67-2
Purity:98% HPLC Package:100mg，250mg，1g
|
|
| | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Basic information |
| Product Name: | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester | | Synonyms: | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester;Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1′-[dithiobis(2,1-ethanediyl-1,4-pip eridinediyl-2,1-ethanediyl)] ester(SSPalmO-Phe);O-Ph-P4C2 | | CAS: | 2377474-67-2 | | MF: | C70H112N2O8S2 | | MW: | 1173.79 | | EINECS: | | | Product Categories: | LNP | | Mol File: | 2377474-67-2.mol | ![Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Structure](CAS/20211123/GIF/2377474-67-2.gif) |
| | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Chemical Properties |
| Boiling point | 1028.5±65.0 °C(Predicted) | | density | 1.038±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Ethanol: soluble | | pka | 8.85±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Usage And Synthesis |
| Biological Activity | SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material (SSPalm; pKa = 5.97 in a TNS binding assay).1,2 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, and antisense oligonucleotides (ASOs). Intravenous administration of mouse erythropoietin (EPO) mRNA in SSPalmO-Phe-containing LNPs increases serum EPO levels in mice.1 | | References | 1.Tanaka, H., Takahashi, T., Konishi, M., et al.Self-degradable lipid-like materials based on "hydrolysis accelerated by the intra-particle enrichment of reactant (HyPER)" for messenger RNA deliveryAdv. Funct. Mater.301910575(2020)
2.Tanaka, H., Takata, N., Sakurai, Y., et al.Delivery of oligonucleotides using a self-degradable lipid-like materialPharmaceutics13(4)544(2021) |
| | Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Preparation Products And Raw materials |
|