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1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-

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1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Glucosylceramide synthase-IN-1
CAS:2601393-20-6
Purity:99% Package:$380.9/5mg;$620.9/10mg;$1250.9/25mg;Bulk package Remarks:99%
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:Glucosylceramide synthase-IN-1
CAS:2601393-20-6
Purity:95% Package:2mg
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Products Intro: Product Name:Glucosylceramide synthase-IN-1
CAS:2601393-20-6
Purity:>=99% Package:100mg;10mg;5mg;50mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:Glucosylceramide synthase-IN-1
CAS:2601393-20-6
Purity:0 Package:2mg/RMB 2650
1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Basic information
Product Name:1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-
Synonyms:1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-;Glucosylceramide synthase-IN-1
CAS:2601393-20-6
MF:C24H20F4N2O3
MW:460.42
EINECS:
Product Categories:
Mol File:2601393-20-6.mol
1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Structure
1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Chemical Properties
Boiling point 575.6±50.0 °C(Predicted)
density 1.363±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka14.39±0.29(Predicted)
color White to off-white
Safety Information
MSDS Information
1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Usage And Synthesis
Biological ActivityGlucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research[1]. Glucosylceramide synthase-IN-1 (T-036) potently reduces the GCS product, catalyze glucosylceramide (GlcCer), in the fibroblasts with Gaucher's disease (EC50 of 7.6 nM)[1]. Glucosylceramide synthase-IN-1 (T-036) has good oral exposure (BA = 67%) and moderate brain penetration (Kpuu,brain = 0.11). Administration of a single dose of Glucosylceramide synthase-IN-1 (T-036) reduces GlcCer in the plasma and cerebral cortex of wild-type mice, and administration of Glucosylceramide synthase-IN-1 (T-036) for 2 months significantly reduces glucosylsphingosine (GlcSph) in the cerebral cortex of the Gaucher's disease mouse model[1].
References[1]. Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- Preparation Products And Raw materials
Tag:1H-Pyrrolo[3,4-c]pyridin-1-one, 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-(2601393-20-6) Related Product Information