| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
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| Products Intro: |
Remarks:clone HV-1, purified immunoglobulin, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-HUMAN FACTOR V Basic information |
| Product Name: | ANTI-HUMAN FACTOR V | | Synonyms: | ANTI-FACTOR V (LIGHT CHAIN);ANTI-FACTOR V (HEAVY CHAIN);ANTI-FACTOR V, HUMAN;ANTI-HUMAN FACTOR V, LIGHT CHAIN;ANTI-HUMAN FACTOR V;Monoclonal Anti-Factor V antibody produced in mouse | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HUMAN FACTOR V Structure]() |
| | ANTI-HUMAN FACTOR V Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-HUMAN FACTOR V Usage And Synthesis |
| Uses | Monoclonal Anti-Factor V antibody produced in mouse has been used in dot blot and enzyme linked immunosorbent assay (ELISA). | | General Description | Monoclonal Anti-Factor V (mouse IgG1 isotype) is derived from the HV-1 hybridoma, produced by the fusion of mouse myeloma Sp2/0-Ag14 cells and splenocytes from BALB/c mouse immunized with Factor V, purified from human plasma. Blood coagulation factor V, also known as, proaccelerin or labile factor. The activated factor V (factor Va) is a calcium dependent heterodimer composed of heavy chain (~105 kDa) and light chain (~73 kDa). | | Biochem/physiol Actions | Blood coagulation factor V is an essential component of the prothrombinase complex that catalyzes the rapid conversion of prothrombin to thrombin and is involved in intrinsic and extrinsic coagulation pathways. About 20% of blood factor V is contained within platelets. Factor V circulates in the plasma as a single chain glycoprotein with little or no intrinsic procoagulant activity. It is activated through limited proteolysis by thrombin, factor Xa, or the factor V activator from Russell′s viper venom (RW-V). Activated protein C (APC) with its cofactor protein S, inactivates factors Va and VIIIa to provide a major natural anticoagulant system. APC resistance known as factor V Leiden (FV Leiden) is a common hereditary thrombophilia Factor V mutation, caused by arginine substitution into glutamine at position 506 (R506Q). |
| | ANTI-HUMAN FACTOR V Preparation Products And Raw materials |
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