Company Name: |
Riedel-de Haen AG
|
Tel: |
800 558-9160 |
Email: |
|
Products Intro: |
Remarks:clone HV-1, purified immunoglobulin, buffered aqueous solution
|
Company Name: |
SIGMA-RBI
|
Tel: |
800 736 3690 (Orders) |
Email: |
|
Products Intro: |
|
|
| ANTI-HUMAN FACTOR V Basic information |
Product Name: | ANTI-HUMAN FACTOR V | Synonyms: | ANTI-FACTOR V (LIGHT CHAIN);ANTI-FACTOR V (HEAVY CHAIN);ANTI-FACTOR V, HUMAN;ANTI-HUMAN FACTOR V, LIGHT CHAIN;ANTI-HUMAN FACTOR V;Monoclonal Anti-Factor V antibody produced in mouse | CAS: | | MF: | | MW: | 0 | EINECS: | | Product Categories: | | Mol File: | Mol File | ![ANTI-HUMAN FACTOR V Structure]() |
| ANTI-HUMAN FACTOR V Chemical Properties |
storage temp. | -20°C | form | buffered aqueous solution |
| ANTI-HUMAN FACTOR V Usage And Synthesis |
Uses | Monoclonal Anti-Factor V antibody produced in mouse has been used in dot blot and enzyme linked immunosorbent assay (ELISA). | General Description | Monoclonal Anti-Factor V (mouse IgG1 isotype) is derived from the HV-1 hybridoma, produced by the fusion of mouse myeloma Sp2/0-Ag14 cells and splenocytes from BALB/c mouse immunized with Factor V, purified from human plasma. Blood coagulation factor V, also known as, proaccelerin or labile factor. The activated factor V (factor Va) is a calcium dependent heterodimer composed of heavy chain (~105 kDa) and light chain (~73 kDa). | Biochem/physiol Actions | Blood coagulation factor V is an essential component of the prothrombinase complex that catalyzes the rapid conversion of prothrombin to thrombin and is involved in intrinsic and extrinsic coagulation pathways. About 20% of blood factor V is contained within platelets. Factor V circulates in the plasma as a single chain glycoprotein with little or no intrinsic procoagulant activity. It is activated through limited proteolysis by thrombin, factor Xa, or the factor V activator from Russell′s viper venom (RW-V). Activated protein C (APC) with its cofactor protein S, inactivates factors Va and VIIIa to provide a major natural anticoagulant system. APC resistance known as factor V Leiden (FV Leiden) is a common hereditary thrombophilia Factor V mutation, caused by arginine substitution into glutamine at position 506 (R506Q). |
| ANTI-HUMAN FACTOR V Preparation Products And Raw materials |
|