147340-43-0
中文名称 | 147340-43-0 |
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中文同义词 | 化合物 T13772 |
英文名称 | MHP 133 |
英文同义词 | MHP 133 |
CAS号 | 147340-43-0 |
分子式 | C17H20ClN5O3 |
分子量 | 377.83 |
EINECS号 | |
相关类别 | |
Mol文件 | 147340-43-0.mol |
结构式 |
147340-43-0 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
AChE 69 μM (Ki) |
muscarinic M1 receptor
|
muscarinic M2 receptor
|
5-HT 4 Receptor
|
MHP-133 is be active (>50% displacement or activity) against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP-133 exhibits this nicotinic-like activity in the cell line. Although the ED 50 for inducing TrkA expression is only about 1 μM, it does predicts the cytoprotective action of MHP-133 in differentiated PC-12 cells deprived of growth factor for 24 h. MHP-133 (10-100 μM) significantly increases the levels of sAPP from cultured astrocytes by 40-60%. MHP-133 produces a bi-phasic effect on slice survival, particularly in the dentate gyrus and the CA1 regions.
In rats, MHP-133 (50, 100, or 200 μg/kg, i.p.) enhances acquisition of the task and increases task accuracy. MHP-133 elicits significant improvements in task accuracies during sessions initiated 10 min after dosing.