KB-5246
| 中文名称 | KB-5246 |
|---|---|
| 中文同义词 | 化合物 T11744;化合物 KB-5246 |
| 英文名称 | KB 5246 |
| 英文同义词 | KB 5246;KB 5246,KB5246 |
| CAS号 | 119474-55-4 |
| 分子式 | C18H17ClFN3O4S |
| 分子量 | 425.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 119474-55-4.mol |
| 结构式 |  |
KB-5246 性质
| 熔点 | 287 °C (decomp) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
Bacterial
KB-5246 is a tetracyclic quinolone and displays antibacterial activities. The MICs for 90% of isolates tested (MIC90s) of KB-5246 against gram-positive microorganisms such as Staphylococcus aureus , including methicillin-resistant S. aureus , Staphylococcus epidermidis , Streptococcus pneumoniae , and Streptococcus pyogenes , are 0.39 μg/mL. KB5246 inhibits 90% of isolates of Escherichia coli , Klebsiella pneumoniae , Klebsiella oxytoca at a concentration of 0.10 μg/mL or less. When a concentration of KB-5246 at the MIC or higher is added, no regrowth after 24 h of incubation is observed.
The 50% effective dose values of KB-5246 against S. pneumoniae 2132 infections are 50.5 mg/kg of body weight. The activities of KB-5246 against S. aureus Smith, P. aeruginosa GN11189, and Serratia marcescens GN7577 infections are comparable to those of ofloxacin and greater than those of norfloxacin.