108852-42-2

108852-42-2

中文名称108852-42-2
中文同义词化合物 T17277;3-乙基 5-(2-(哌啶-1-基)乙基) 2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯
英文名称diperdipine
英文同义词diperdipine;YS-201;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-[2-(1-piperidinyl)ethyl] ester;YS201,YS 201;3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;3-Ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate , YS-201
CAS号108852-42-2
分子式C24H31N3O6
分子量457.52
EINECS号
相关类别
Mol文件108852-42-2.mol
结构式108852-42-2 结构式

108852-42-2 性质

沸点593.9±50.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
储存条件Store at -20°C
溶解度溶于二甲基亚砜
形态固体
酸度系数(pKa)8.29±0.10(Predicted)
颜色浅黄至黄色

108852-42-2 用途与合成方法

YS-201是二氢吡啶类钙通道 (calcium channel) 拮抗剂,有潜力用于心绞痛和高血压的研究。

YS-201 (Diperdipine) markedly reduces systemic vascular resistance and improves stroke index and left ventricular ejection fraction. Mean pulmonary artery and wedge pressures are slightly increased as a possible consequence of enhanced venous return, whereas right atrial and left ventricular end-diastolic pressures are not significantly changed. Nevertheless, an increase in preload is clearly indicated by an augmented left ventricular end-diastolic volume index after administration of diperdipine. After intravenous and oral doses, absolute bioavailability is calculated to be 18.7%. Biliaryexcretion accounts for about 0.1% of the total clearance of diperdipine and does not contribute to the overall elimination of the drug. After intraportal administration, the bioavailable fraction of diperdipine is increasing up to 44.3% suggesting a prehepatic site of loss of the drug. The single application of diperdipine to mice and rats by gavage causes intolerance reactions starting at the lowest tested dose level of 200 mg/kg b.w. p.o. (mice) and at 250 mg/kg b.w. p.o. (rats). In the rat, toxic effects occur from 15 mg diperdipine/kg b.w./day p.o. onwards.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/04/30HY-U00137108852-42-2
YS-201
108852-42-21mg2000元
2024/04/30HY-U00137108852-42-2
YS-201
108852-42-25mg4000元

108852-42-2 上下游产品信息

"108852-42-2"相关产品信息
YS121 YS-035HYDROCHLORIDE 1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐
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