| Company Name: |
Nanjing Peptide Biotech Ltd.
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| Tel: |
025-025-58361106-805-805 13082558573 |
| Email: |
liugang@njpeptide.com |
| Products Intro: |
Product Name:Peptide 78
CAS:132116-62-2
Purity:90%HPLC,95%HPLC,98%HPLC Package:5mg,20mg,100mg,250mg,500mg,1g
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:Peptide 78
CAS:132116-62-2
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
|
| Tel: |
0571-87213919 17306812703 |
| Email: |
3007955328@qq.com |
| Products Intro: |
Product Name:Peptide 78
CAS:132116-62-2
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| | peptide 78 Basic information |
| Product Name: | peptide 78 | | Synonyms: | peptide 78;L-Asparagine, L-threonyl-L-methionyl-L-arginyl-L-lysyl-L-prolyl-L-arginyl-L-serylglycyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-valyl-L-alanyl- (9CI) | | CAS: | 132116-62-2 | | MF: | C62H107N23O21S | | MW: | 1542.72 | | EINECS: | | | Product Categories: | | | Mol File: | 132116-62-2.mol |  |
| | peptide 78 Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Water : 100 mg/mL (64.82 mM; Need ultrasonic) |
| | peptide 78 Usage And Synthesis |
| Biological Activity | Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA)[1].
Peptide 78, a potent PMN chemotaxin, in the conditioned medium of human pulmonary epithelial cells (A549) stimulated with TNF-α (20 ng/mL) or IL-1β (10 ng/mL). Peptide 78 is an 8.3-kD protein with 78 amino acids containing 4 cysteines positioned identically to those of IL-8 and its homologues. Peptide 78 belongs to a supergene family that includes platelet factor-4, platelet basic protein, and its cleavage products (connective tissue activating peptide-III, β-thromboglobulin, and interferon-γ-inducible protein, macrophage inflammatory protein-2α, and macrophage inflammatory protein-2β)[1]. Peptide 78 shares several properties of PMN activation similar to either NAP-2 or LL-8. Peptide 78 stimulation of PMNs results in significant chemotactic activity, release of elastase from cytochalasin-B-pretreated cells, and the induction of free, cytosolic calcium release. Peptide 78 aids in the recruitment of PMNs into inflamed joints of RA. Peptide 78 represents one of the most abundant chemokines present in RA synovial fluid.Peptide 78 in rheumatoid arthritis synovial fluids is biologically active. Peptide 78 appears to account for almost half of the RA synovial fluid PMN chemotactic activity in vitro[1]. | | References | [1]. A E Koch, et al. Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest. 1994 Sep;94(3):1012-8. |
| | peptide 78 Preparation Products And Raw materials |
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