| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Hymeglusin
CAS:29066-42-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | antibiotic 1233A Basic information |
| Product Name: | antibiotic 1233A | | Synonyms: | 1233A;Antibiotic F-244;F-244;L-659699;(R,R)-HyMeglusin;(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid;Hymeglusin;(2E, 4E, 7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid | | CAS: | 29066-42-0 | | MF: | C18H28O5 | | MW: | 324.41 | | EINECS: | | | Product Categories: | | | Mol File: | 29066-42-0.mol |  |
| | antibiotic 1233A Chemical Properties |
| Boiling point | 516.6±15.0 °C(Predicted) | | density | 1.101±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | powder | | pka | 4.98±0.33(Predicted) | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| WGK Germany | 3 | | RTECS | YQ1170000 |
| | antibiotic 1233A Usage And Synthesis |
| Description | Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4 | | Uses | Hymeglusin is an irreversible HMG-CoA synthase inhibitor. | | Definition | ChEBI: Hymeglusin is a long-chain fatty acid. | | storage | +4°C | | References | 1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488
2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22
3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713
4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8 |
| | antibiotic 1233A Preparation Products And Raw materials |
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