111374-21-1
| 中文名称 | 111374-21-1 |
|---|---|
| 中文同义词 | 化合物 T11581;化合物 HSR6071 |
| 英文名称 | HSR 6071 |
| 英文同义词 | HSR 6071;6-(1-Pyrrolidinyl)-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide;N-(1H-Tetrazol-5-yl)-6-(1-pyrrolidinyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, 6-(1-pyrrolidinyl)-N-2H-tetrazol-5-yl-;HSR6071,HSR-6071 |
| CAS号 | 111374-21-1 |
| 分子式 | C10H12N8O |
| 分子量 | 260.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 111374-21-1.mol |
| 结构式 |  |
111374-21-1 性质
| 熔点 | 288-294 °C (decomp)(Solv: dimethyl sulfoxide (67-68-5)) |
|---|---|
| 密度 | 1.555±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.61±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea.
HSR-6071 inhibits the IgE-mediated histamine release with an IC
50
of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-U00133 | 111374-21-1 HSR6071 | 111374-21-1 | 1mg | 1590元 |
| 2024/08/19 | HY-U00133 | 111374-21-1 HSR6071 | 111374-21-1 | 5mg | 3500元 |