| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:6,2',4'-TriMethoxyflavone;2',4',6-TriMethoxyflavone
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:6, 2', 4'-trimethoxyflavone
CAS:720675-90-1
Purity:>=98% (HPLC) Package:10MG Remarks:T4080-10MG
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| | 6,2',4'-TRIMETHOXYFLAVONE Basic information |
| Product Name: | 6,2',4'-TRIMETHOXYFLAVONE | | Synonyms: | 6,2',4'-TRIMETHOXYFLAVONE;Trimethoxyflavone;2',4',6-Trimethoxyflavone;2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dimethoxyphenyl)-2,3-dihydro-6-methoxy-;6,2',4'-Trimethoxyflavone | | CAS: | 720675-90-1 | | MF: | C18H18O5 | | MW: | 314.33 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 6,2',4'-TRIMETHOXYFLAVONE Chemical Properties |
| Boiling point | 482.8±45.0 °C(Predicted) | | density | 1.208±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: >5mg/mL | | form | powder | | color | yellow |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 6,2',4'-TRIMETHOXYFLAVONE Usage And Synthesis |
| Biochem/physiol Actions | 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function. |
| | 6,2',4'-TRIMETHOXYFLAVONE Preparation Products And Raw materials |
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