- CHS-828
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- $1.00 / 1ASSAYS
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2019-09-06
- CAS:200484-11-3
- Min. Order: 1ASSAYS
- Purity: 95%~99%
- Supply Ability: per week:100kg
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| | CHS-828 Basic information |
| Product Name: | CHS-828 | | Synonyms: | GMX 1778;N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine;1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine;GMX1778(CHS-828);2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine;CHS828;CHS 828;GMX1778, >98%;HS-828 | | CAS: | 200484-11-3 | | MF: | C19H22ClN5O | | MW: | 371.86 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 200484-11-3.mol |  |
| | CHS-828 Chemical Properties |
| Melting point | 166-168°C | | Boiling point | 532.1±58.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO: soluble20mg/mL, clear | | pka | 7.36±0.10(Predicted) | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChIKey | BOIPLTNGIAPDBY-UHFFFAOYSA-N |
| | CHS-828 Usage And Synthesis |
| Description | CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo. In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors. | | Uses | GMX1778 is an anticancer agent that inhibits cellular synthesis of NAD. | | Definition | ChEBI: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine is an aromatic ether. | | storage | +4°C | | References | 1) Olesen?et al.?(2008),?Anticancer agent CHS-828 inhibits cellular synthesis of NAD; Biochem. Biophys. Res. Commun.?376?799
2) Hassan?et al. (2006),?CHS 828 kill tumor cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome; Anticancer Res.?26?4431
3) Hjarnaa?et al.?(1999),?CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo; Cancer Res.?59?5751
4) Cerna?et al.?(2012)?Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner; J. Biol. Chem.?287?22408 |
| | CHS-828 Preparation Products And Raw materials |
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