| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:VP 14637
CAS:235106-62-4
Package:100Mg,10Mg
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:VP-14637
CAS:235106-62-4
Purity:98% Package:1G;10G;100G Remarks:VP-14637 is a small molecule inhibitor of respiratory syncytial virus (RSV) with EC50 value of 1.4 nM. It suppresses RSV via binding to the viral F protein and inhibiting the RSV fusion (EC50 = 5.4 nM
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| Company Name: |
Codow Chemical Co.,Ltd.
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| Tel: |
18620099427 |
| Email: |
amy@howeipharm.com |
| Products Intro: |
Product Name:VP 14637
CAS:235106-62-4
Purity:99% Package:1MG;2.5MG;5MG;10MG
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| | 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Basic information |
| | 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Chemical Properties |
| Melting point | >225°C (dec.) | | Boiling point | 816.7±75.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Amber Vial, Refrigerator | | solubility | Aqueous Base (Slightly), DMSO (Slightly) | | form | Solid | | pka | 7.67±0.50(Predicted) | | color | White to Pale Beige | | Stability: | Light Sensitive |
| | 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Usage And Synthesis |
| Uses | Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient populations. VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms by binding into a small hydrophobic cavity in the inner core of F protein, interacting simultaneously with both the HR1 and HR2 domains. | | Biological Activity | ec50: 5.4 nm for rsv fusionvp-14637 is an inhibitor of rsv.respiratory syncytial virus (rsv) is the leading cause of respiratory tract infections in humans. rsv f protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti-rsv treatment. | | in vitro | previous study demonstrated that vp-14637 did not block rsv adsorption but inhibited rsv-induced cell-cell fusion and specifically bound to rsv-infected cells. vp-14637 was capable of specifically interacting with the rsv fusion protein. rsv variants resistant to vp-14637 were selected, in which no mutations arose in hr1, indicating a mechanism other than direct disruption of the heptad repeat interaction. the f proteins containing the resistance mutations exhibited greatly reduced binding of vp-14637 [1]. | | in vivo | in cotton rats, animals given as little as 126 microg/kg of vp-14637 by small droplet aerosol starting 1 day after experimental virus infection with either a rsv a or b subtype consistently had significantly lower mean pulmonary rsv titers and reduced histopathological findings than mock-treated animals or cotton rats given placebo. in addition, no cotton rat treated with vp14637 had any evident untoward responses [2]. | | references | [1] douglas, j. l.,panis, m.l.,ho, e., et al. inhibition of respiratory syncytial virus fusion by the small molecule vp-14637 via specific interactions with f protein. journal of virology 77(9), 5054-5064 (2003).
[2] wyde pr, laquerre s, chetty sn, gilbert be, nitz tj, pevear dc. antiviral efficacy of vp14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol. antiviral res. 2005 oct;68(1):18-26. |
| | 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Preparation Products And Raw materials |
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