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Product Name:Lycopodine
CAS:466-61-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| | lycopodine Basic information |
| Product Name: | lycopodine | | Synonyms: | lycopodine;(15R)-15-Methyllycopodan-5-one;1,9-Ethanobenzo[i]quinolizin-14-one, dodecahydro-11-methyl-, (1S,8aR,9S,11R,12aR)- | | CAS: | 466-61-5 | | MF: | C16H25NO | | MW: | 247.38 | | EINECS: | | | Product Categories: | | | Mol File: | 466-61-5.mol |  |
| | lycopodine Chemical Properties |
| Melting point | 114-115°; mp (racemate) 130-131° | | alpha | D -24° (alc) | | Boiling point | 125 °C(Press: 0.2 Torr) | | density | 1.18 g/cm3 | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.36±0.40(Predicted) | | optical activity | -24.521 (c 1.1, ethanol) |
| | lycopodine Usage And Synthesis |
| Description | This alkaloid has, so far, been discovered in all Lycopodium species with the
exception of L. saururus Lam. It was first obtained by B6deker who assigned to
it the formula C32Hs203N2, altered to that given by Achmatowicz and Uzieblo
and confirmed by Manske and Marion. It forms colourless prisms from Et20 and
has [α]20D - 9.01 ° (Me2CO). It yields crystalline salts and derivatives: the perchlorate, m.p. 276°C; methochloride, m.p. 238-240°C, methiodide, m.p. 335-
7°C and a hydrazone, mop. 20B-2l0°C. According to Bodeker it also yields a
crystalline hydrochloride and aurichloride.
Even under pressure at 200°C in the presence of Raney Ni, the base cannot be
hydrogenated. On selenium dehydrogenation, a complex mixture of bases is
formed from which 7 -methylquinoline and 5:7 -dimethylquinoline have been
identified. 7 -methylquinoline is also stated to be formed when the base is heated
with palladium as catalyst. A stereospecific total synthesis of the (±)-form has
been described. | | Definition | ChEBI: Lycopodine is a quinolizidine alkaloid. It derives from a hydride of a lycopodane. | | References | Bodeker., Annalen., 208,363 (1881)
Achmatowicz, Uzieblo., Rocz. Chern., 18,89 (1938)
Manske, Marion., Can. 1. Res., 20B, 87 (1942)
Marion, Manske., ibid, 20B, 153 (1942)
Manske, Marion., 1. Arner. Chern. Soc., 69,2126 (1947)
Anet., Tetrahedron Lett., 20, 13 (1960)
Harrison et al., Can. 1. Chern., 39,2086 (1961) |
| | lycopodine Preparation Products And Raw materials |
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