| Company Name: |
Scandinavian Formulas
|
| Tel: |
800-688-2276 |
| Email: |
mikep@scandinavianformulas.com |
| Products Intro: |
Product Name:St. Johns Wort Oil
|
| Company Name: |
Aadinath Organic
|
| Tel: |
08048980498 |
| Email: |
|
| Products Intro: |
Product Name:St John's Wort Oil
|
|
| | ST JOHN'S WORT Basic information |
| Product Name: | ST JOHN'S WORT | | Synonyms: | ST JOHN'S WORT OIL;ST JOHN'S WORT | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ST JOHN'S WORT Structure]() |
| | ST JOHN'S WORT Chemical Properties |
| | ST JOHN'S WORT Usage And Synthesis |
| Occurrence | St. John's wort is found in Europe, Asia, and the United States. | | Uses | St. John's wort is used to treat mild to moderate depression and anxiety. It may be used topically as an antiinfl ammatory to relieve hemorrhoids, as well as to treat vitiligo and burns. | | Indications | St. John’s wort (Hypericum perforatum) is a yellowflowered
perennial European herb that has become
widely naturalized in the United States. Its name is
derived from the Old English word for plant, wort, and
from the fact that it often starts blooming around June
24, St. John’s day. Although St. John’s wort has traditionally
been used for wound healing, insomnia,
rheumatism, and depression, it is most popular today
for the treatment of mild to moderate depression.
The leafy parts of the herb contain naphthodianthrones
(e.g., hypericin), flavonoids (e.g., quercetin),
and phloroglucinols (e.g., hypaphorine). Although this
herb is now commonly standardized for its hypericin
content, it appears that its other constituents may also
be just as pharmacologically active. | | Mechanism of action | Just how St. John’s wort treats depression is not clearly
understood. It is possible that this herb’s various components
may work synergistically rather than through a
single active substance, mimicking the action of traditional
antidepressants. High concentrations can affect in
vitro serotonin reuptake, but it is unclear whether this
would occur in a patient taking standard oral doses.The
hypaphorine constituent may possess serotonin reuptake
inhibitor activity, and it also inhibits synaptic uptake
of amino butyric acid (GABA) and L-glutamate.
Earlier studies demonstrated some monoamine oxidase
inhibition, but this action now seems unlikely to be clinically
relevant. Flavonoid components and hypericin
also may weakly inhibit catechol-O-methyl-transferase
(COMT). Melatonin, surprisingly, has also been identified
in St. John’s wort and may play a role in its sleepenhancing
and antidepressant effects. | | Clinical Use | St. John’s wort is very popular as a physician-prescribed
antidepressant in Europe and is widely used for this
purpose—usually without medical guidance—in the
United States.A meta-analysis of 23 studies concluded
that St. John’s wort was more effective than placebo in
treating mild to moderate depression and was as effective
as imipramine and standard antidepressants. It was
also better tolerated than the antidepressants to which
it was compared. A recent meta-analysis, however,
failed to find St. John’s wort effective for severe depression. | | Side effects | St. John’s wort is usually well tolerated, but insomnia,
dizziness, fatigue, restlessness, GI upset, constipation,
dry mouth, and allergy are reported as possible side effects.
Hypomania has also been reported in several
cases, and rarely, photosensitivity can be a problem following
high doses; hypericin seems to be the component
responsible for the photosensitivity. Sun-induced neuropathy
has also been described, and it is possible that
hypericin may also increase the risk of cataracts with
prolonged use.While a prior allergy to the herb is the
main contraindication, St. John’s wort should also be
avoided in pregnant and breast-feeding women (it may
increase uterine tone) and in children until its safety is
further established.
A major emerging concern in St. John’s wort use is
the numerous clinically significant herb–drug interactions
that have been reported. St. John’s wort appears to
be a major inducer of the cytochrome P450 3A4
(CYP3A4) enzyme system in the liver.This first came to
light following acute heart transplant rejection in a person
taking cyclosporin and St. John’s wort. The cyclosporin
levels remained subtherapeutic until St.
John’s wort was discontinued. A similar phenomenon
was noted with AIDS patients taking protease inhibitors
and nonnucleoside reverse transcriptase inhibitors
(NNRTIs). Concomitant use of St. John’s wort reduced
the effectiveness of these medicines as well. Since then,
St. John’s wort has been shown to reduce plasma levels
of digoxin, warfarin, theophylline, and oral contraceptives.
Breakthrough bleeding has been observed in
young women taking this herb, and patients starting
oral contraceptives should be counseled to use backup
contraception if they take St. John’s wort or antibiotics.
St. John’s wort can adversely affect many other common
medications, including nonsedating antihistamines,
antifungals, chemotherapeutic agents, and calcium channel
blockers.
SSRIs should not be taken with St. John’s wort because
of the risk of the onset of a serotonin syndrome
characterized by nausea, tremor, and weakness.Alcohol
also should be avoided. St. John’s wort can increase
opioid-induced sleep. |
| | ST JOHN'S WORT Preparation Products And Raw materials |
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