| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-CFTR
Purity:Prestige Antibodies P Package:100μL Remarks:HPA021939
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| | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Basic information |
| Product Name: | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | | Synonyms: | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;ANTI-HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;ANTI-HUMAN ELT;ANTI-CFTR;ANTI-ABCC7;Anti-CFTR antibody produced in rabbit;ABCC7;cAMP- dependent chloride channel | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Structure]() |
| | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Usage And Synthesis |
| Uses | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | General Description | CFTR (Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C, member 7) is a membrane-associated, N-linked glycoprotein. | | Biochem/physiol Actions | CFTR (Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C, member 7) is mainly involved in the regulation of Na+ and Cl- transport by acting as a linear, cAMP activated, chloride channel. In addition, it is also associated with different transport signaling pathways. It has been reported that CFTR controls functionality of outwardly rectifying Cl- channels (ORCCs) by facilitating the transport and delivery of potent autacoid agonist and ORCC regulator ATP. It has also been suggested that CFTR can interact with Na+-reabsorptive pathway. CFTR is associated with congenital bilateral absence of the vas deferens (CBAVD) and causes the genital form of cystic fibrosis (CF). The CFTR gene may also responsible for male infertility. |
| | ANTI-CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Preparation Products And Raw materials |
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