4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
中文名称 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟 |
---|---|
中文同义词 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟;化合物AP 18 |
英文名称 | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime |
英文同义词 | AP-18;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal |
CAS号 | 55224-94-7 |
分子式 | C11H12ClNO |
分子量 | 209.67 |
EINECS号 | |
相关类别 | Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 55224-94-7.mol |
结构式 | ![]() |
4-(4-氯苯基)-3-甲基丁-3-烯-2-肟 性质
储存条件 | 2-8°C |
---|---|
溶解度 | 二甲基亚砜:>10mg/mL |
形态 | 固体 |
颜色 | 白色至类白色 |
稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
TRPA1 ~3 μM (IC 50 ) |
At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca 2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes .
AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-W014421 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟 AP-18 | 55224-94-7 | 10 mg | 1400元 |
2024/04/30 | HY-W014421 | 4-(4-氯苯基)-3-甲基丁-3-烯-2-肟 AP-18 | 55224-94-7 | 50 mg | 4600元 |