STEM-CELL FACTOR/C-KIT 抑制剂
中文名称 | STEM-CELL FACTOR/C-KIT 抑制剂 |
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中文同义词 | STEM-CELL FACTOR/C-KIT 抑制剂;化合物ISCK03;4-(1,1-二甲基乙基)-N-(4-(1H-咪唑-1-基)苯基)苯磺酰胺;ISCK03,SCF / C-KIT抑制剂 |
英文名称 | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- |
英文同义词 | [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-;ISCK03;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl];ISCK 03; ISCK-03;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem |
CAS号 | 945526-43-2 |
分子式 | C19H21N3O2S |
分子量 | 355.45 |
EINECS号 | |
相关类别 | API |
Mol文件 | 945526-43-2.mol |
结构式 |
STEM-CELL FACTOR/C-KIT 抑制剂 性质
储存条件 | Sealed in dry,2-8°C |
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溶解度 | 溶于乙醇或DMSO |
形态 | 固体 |
颜色 | 粘黄色 |
敏感性 | Light Sensitive |
InChIKey | XQABBHBFHWHMKF-UHFFFAOYSA-N |
Target | Value |
SCF
() | |
c-Kit
() |
Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions.
Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制剂 ISCK03 | 945526-43-2 | 5mg | 600元 |
2024/04/30 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制剂 ISCK03 | 945526-43-2 | 10mM * 1mLin DMSO | 660元 |