| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:Pyridomycin
CAS:18791-21-4
Purity:>95% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:Pyridomycin
CAS:18791-21-4
Purity:>95% by HPLC Package:1mg;5mg
|
|
| | Pyridomycin Basic information |
| Product Name: | Pyridomycin | | Synonyms: | 3-Hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridylmethyl)-1,4-dioxa-8-azacyclododeca-6-yl]-2-pyridinecarboxamide;Pyridomycin;2-Pyridinecarboxamide, 3-hydroxy-N-[(2Z,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-2-(1-methylpropylidene)-3,7,12-trioxo-9-(3-pyridinylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]- | | CAS: | 18791-21-4 | | MF: | C27H32N4O8 | | MW: | 540.57 | | EINECS: | | | Product Categories: | | | Mol File: | 18791-21-4.mol |  |
| | Pyridomycin Chemical Properties |
| Melting point | 222° | | Boiling point | 616.01°C (rough estimate) | | density | 1.3105 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | pka | 11.54±0.70(Predicted) |
| | Pyridomycin Usage And Synthesis |
| Description | Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml). | | Uses | Pyridomycin is a potent antibiotic active against mycobacteria. | | Uses | Pyridomycin is a potent antibiotic active against mycobacteria and some Gram negative bacteria, originally isolated from Streptomyces abidoflavus by Umezawa group at the NIH Japan in 1953, and since isolated from different species and published under several names. The unusual 12-membered macrocyclic depsipeptide comprises three unique sub-units incorporating two substituted pyridines. Pyridomycin is thought to target NADH-dependent enoyl (acyl-carrier-protein) reductase InhA. Recent reports of activity against isoniazid-resistant mycobacteria has seen pyridomycin identified as a potential lead for new generation antibiotics. |
| | Pyridomycin Preparation Products And Raw materials |
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