YM 872
| 中文名称 | YM 872 |
|---|---|
| 中文同义词 | 唑南帕奈;化合物 T17276;2-(7-(1H-咪唑-1-基)-6-硝基-2,3-二氧代-3,4-二氢喹喔啉-1(2H)-基)乙酸 |
| 英文名称 | ZONAMPANEL |
| 英文同义词 | ZONAMPANEL;(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate;1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dihydro-;7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalineacetic acid;Zonampanel (YM 872);1(2H)-Quinoxalineacetic acid, 3,4-dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo- |
| CAS号 | 210245-80-0 |
| 分子式 | C13H9N5O6 |
| 分子量 | 331.24 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 210245-80-0.mol |
| 结构式 |  |
YM 872 性质
| 密度 | 1.82±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.20±0.10(Predicted) |
| 颜色 | 黄至棕色 |
Zonampanel inhibits the human MRP4-mediated transport of [ 3 H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [ 3 H]oestradiol 17-D-glucuronide or [ 3 H]methotrexate. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (K i ) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [ 14 C]Zonampanel uptake is observed in these cells [K m values: 13.4 to 53.6 μM].
In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-15072 | Zonampanel | 1 mg | 2000元 | |
| 2024/08/19 | HY-15072 | YM 872 Zonampanel | 210245-80-0 | 5mg | 5000元 |