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Amatek Scientific Co. Ltd.
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0512-56316828 |
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info@amateksci.com |
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Product Name:6,9-Dichloro-1,2,3,4-tetrahydroacridine
CAS:5396-25-8
Purity:97% HPLC Package:5g;25g;100g;1kg
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Biokitchen
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021-021-021-31663258 13795219287 |
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Product Name:6,9-dichloro-1,2,3,4-tetrahydroacridine
CAS:5396-25-8
Purity:> 97% HPLC Package:10G;100G；500G；1KG; 5KG, 10KG; 100KG
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| Company Name: |
Sichuan BaiPeng Biotechnology Co., Ltd.
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028-65791793 18140026355 |
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568470422@qq.com |
| Products Intro: |
Product Name:6,9-dichloro-1,2,3,4-tetrahydroacridine
CAS:5396-25-8
Purity:95 Package:10G;100G;1KG;5KG
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| Company Name: |
Aikon International Limited
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025-58851090 13611564524 |
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lwan@aikonchem.com |
| Products Intro: |
Product Name:6,9-Dichloro-1,2,3,4-tetrahydroacridine
CAS:5396-25-8
Purity:95+% Package:1g;5g;10g
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:6,9-Dichloro-1,2,3,4-tetrahydroacridine
CAS:5396-25-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Basic information |
| Product Name: | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE | | Synonyms: | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE;ACRIDINE, 6,9-DICHLORO-1,2,3,4-TETRAHYDRO-;6-Chloro-9-Chloro-1,2,3,4-Tetrahydroacridine | | CAS: | 5396-25-8 | | MF: | C13H11Cl2N | | MW: | 252.14 | | EINECS: | | | Product Categories: | | | Mol File: | 5396-25-8.mol |  |
| | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml | | form | A crystalline solid |
| | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Usage And Synthesis |
| Biological Activity | 6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1 It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 | | References | 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analoguesJ. Med. Chem.43(10)2007-2018(2000)
2.Digiacomo, M., Chen, Z., Wang, S., et al.Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of ADBioorg. Med. Chem. Lett.25(4)807-810(2015)
3.Li, S.Y., Jiang, N., Xie, S.S., et al.Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's diseaseOrg. Biomol. Chem.12(5)801-814(2014) |
| | 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Preparation Products And Raw materials |
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