|
|
| | Z-Vad-fmk, non-methylated Basic information |
| Product Name: | Z-Vad-fmk, non-methylated | | Synonyms: | Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Z-VAD-FMK (Caspase Inhibitor VI);Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci);L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-;Z-VAD-FMK, Free Acid;Z-VAD(OH)-FMK (Caspase Inhibitor VI) | | CAS: | 161401-82-7 | | MF: | C21H28FN3O7 | | MW: | 453.46 | | EINECS: | | | Product Categories: | | | Mol File: | 161401-82-7.mol |  |
| | Z-Vad-fmk, non-methylated Chemical Properties |
| Boiling point | 758.0±60.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) | | pka | 3.91±0.19(Predicted) | | form | Off-white solid | | color | White to light yellow |
| | Z-Vad-fmk, non-methylated Usage And Synthesis |
| Description | Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use. | | General Description | An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available. | | Biochem/physiol Actions | Product does not compete with ATP. |
| | Z-Vad-fmk, non-methylated Preparation Products And Raw materials |
|